Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia

Abstract An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 108 red blood cells, respectively. Maternal 6TGN levels could be u...

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Main Authors: Hidehiko Maruyama (Author), Katsuhiko Tada (Author), Takuzo Fujiwara (Author), Kosuke Ota (Author), Misao Kageyama (Author)
Format: Book
Published: Thieme Medical Publishers, Inc., 2013-05-01T00:00:00Z.
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Summary:Abstract An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 108 red blood cells, respectively. Maternal 6TGN levels could be useful in predicting neonatal pancytopenia.
Item Description:2157-6998
2157-7005
10.1055/s-0032-1329683