Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors

• Autori principali: Mehmet Onyılmaz (Autore), Murat Koca (Autore), Alessandro Bonardi (Autore), Mustafa Degirmenci (Autore), Claudiu T. Supuran (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Isocoumarins, isomeric to comarins which act as effective carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, were investigated for the first time as inhibitors of this enzyme. A series of 3-substituted and 3,4-disubstituted isocoumarins incorporating phenylhydrazone, 1-phenyl-pyrazole and pyrazolo-subs...