A Novel Lactose/MCC/L-HPC Triple-Based Co-Processed Excipients with Improved Tableting Performance Designed for Metoclopramide Orally Disintegrating Tablets
New co-processed excipients comprising lactose (filler and sweetener), microcrystalline cellulose (MCC, filler), and low-substituted hydroxypropyl cellulose (L-HPC, disintegrant and binder) were developed via solvent evaporation for the preparation of metoclopramide orally disintegrating tablets (MC...
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MDPI AG,
2024-07-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_b14a2f3e41bb442a8e35d481fb8d015a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Xiaorong Dai |e author |
| 700 | 1 | 0 | |a Jiamin Wang |e author |
| 700 | 1 | 0 | |a Bo Yan |e author |
| 700 | 1 | 0 | |a Qian Wang |e author |
| 700 | 1 | 0 | |a Yan Shen |e author |
| 700 | 1 | 0 | |a Yongkang Chen |e author |
| 700 | 1 | 0 | |a Yu Tian |e author |
| 245 | 0 | 0 | |a A Novel Lactose/MCC/L-HPC Triple-Based Co-Processed Excipients with Improved Tableting Performance Designed for Metoclopramide Orally Disintegrating Tablets |
| 260 | |b MDPI AG, |c 2024-07-01T00:00:00Z. | ||
| 500 | |a 10.3390/pharmaceutics16070959 | ||
| 500 | |a 1999-4923 | ||
| 520 | |a New co-processed excipients comprising lactose (filler and sweetener), microcrystalline cellulose (MCC, filler), and low-substituted hydroxypropyl cellulose (L-HPC, disintegrant and binder) were developed via solvent evaporation for the preparation of metoclopramide orally disintegrating tablets (MCP ODTs). Single-factor and Box-Behnken experimental designs were employed to optimize the formulation. The optimized formulation ratios were water: MCC: lactose (g/g) = 17.26:2.79:4.54:1. The results demonstrated that particles formed by solvent evaporation had superior flowability and compressibility compared to the physical mixture. Tablets compressed with these co-processed excipients exhibited a significantly reduced disintegration time of less than 25 s and achieved complete dissolution within 5 min. Pharmacokinetic studies revealed that MCP ODTs significantly improved C<sub>max</sub>, which was 1.60-fold higher compared to conventional tablets. In summary, the lactose/L-HPC/MCC triple-based co-processed excipients developed in this study are promising and could be successfully utilized in orally disintegrating and fast-release tablets. | ||
| 546 | |a EN | ||
| 690 | |a co-processed excipients | ||
| 690 | |a metoclopramide | ||
| 690 | |a orally disintegrating tablets | ||
| 690 | |a pharmacokinetics | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 16, Iss 7, p 959 (2024) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/16/7/959 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/b14a2f3e41bb442a8e35d481fb8d015a |z Connect to this object online. |