Recurrent upper respiratory tract infections in early childhood: a newly defined clinical condition

Abstract Background Recurrent Upper Respiratory Tract Infections (R-URTIs) pose a significant challenge in pediatric healthcare, affecting both children and their families. This study aimed to investigate the prevalence, risk factors, and clinical implications of R-URTI in children aged 0-5 years. M...

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Main Authors: Antonio Corsello (Author), Gregorio Paolo Milani (Author), Marina Picca (Author), Roberto Buzzetti (Author), Romeo Carrozzo (Author), Mirko Gambino (Author), Giovanni Chiaffoni (Author), Paola Marchisio (Author), Chiara Mameli (Author)
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Published: BMC, 2024-02-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Antonio Corsello  |e author 
700 1 0 |a Gregorio Paolo Milani  |e author 
700 1 0 |a Marina Picca  |e author 
700 1 0 |a Roberto Buzzetti  |e author 
700 1 0 |a Romeo Carrozzo  |e author 
700 1 0 |a Mirko Gambino  |e author 
700 1 0 |a Giovanni Chiaffoni  |e author 
700 1 0 |a Paola Marchisio  |e author 
700 1 0 |a Chiara Mameli  |e author 
245 0 0 |a Recurrent upper respiratory tract infections in early childhood: a newly defined clinical condition 
260 |b BMC,   |c 2024-02-01T00:00:00Z. 
500 |a 10.1186/s13052-024-01600-5 
500 |a 1824-7288 
520 |a Abstract Background Recurrent Upper Respiratory Tract Infections (R-URTIs) pose a significant challenge in pediatric healthcare, affecting both children and their families. This study aimed to investigate the prevalence, risk factors, and clinical implications of R-URTI in children aged 0-5 years. Methods This observational study involved a sample of 483 children aged 0-5 years, focusing on establishing a practical and dynamic definition of R-URTI. Family pediatricians prospectively collected socio-demographic information, medical history, and recorded the occurrence of URTI episodes. Children were followed from recruitment until March 2021, predating the COVID-19 outbreak. Results A substantial prevalence of R-URTIs was found, estimating it at 5-10% among this age group. To define R-URTI, a practical and dynamic criterion was proposed: children experiencing a minimum of four URTI episodes, each lasting four days or more, within a six-month period, with intervals of well-being in between. Conclusions The study highlighted that specific risk factors for R-URTI were elusive, suggesting that this condition may affect children regardless of their family or clinical history. Moreover, the study's stratification by age group and times of observation facilitated patient-specific clinical decision-making. The proposed definition may represent a valuable tool for clinicians in diagnosing and addressing R-URTI cases. 
546 |a EN 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Italian Journal of Pediatrics, Vol 50, Iss 1, Pp 1-5 (2024) 
787 0 |n https://doi.org/10.1186/s13052-024-01600-5 
787 0 |n https://doaj.org/toc/1824-7288 
856 4 1 |u https://doaj.org/article/b14cce90f24e4035aedff9a7d3df3db8  |z Connect to this object online.