Expression of Monomeric C-Reactive Protein in Infarcted Brain Tissue from Patients with Alzheimer's Disease

• Main Authors: Mark SLEVIN (Author), Donghui LIU (Author), Glenn FERRIS (Author), Malik AL-HSINAWI (Author), Raid AL-BARADIE (Author), Jerzy KRUPINSKI (Author)
• Format: Book
• Published: Federation of Turkish Pathology Societies, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.5146/tjpath.2016.01374; 1018-5615; 1309-5730
• Keywords: Monomeric C-reactive protein; Stroke; Alzheimer's disease; Neurodegeneration; Vascular dementia; Pathology; RB1-214
• Source: Türk Patoloji Dergisi, Vol 33, Iss 1, Pp 25-29 (2017)

Objective: We have previously shown that monomeric-C-reactive protein is deposited in significant quantities within the brain parenchyma after stroke. Since we have recently identified a possible role of this protein in supporting neurodegeneration and aberrant vascular development we identified a small group of post-mortem brain samples from individuals who had Alzheimer's disease and evidence of tissue infarction/ micro-infarction on histological examination. Material and Method: We used immunohistochemistry staining to identify the monomeric-C-reactive protein expressed in the infarcted brain tissues. Results: We showed that monomeric-C-reactive protein deposition was highest in those regions affected by stroke or vascular disruption, and that within those same areas, there was more interaction and co-localization between major classical proteins of neurodegeneration (β-amyloid and tau). Conclusion: We hypothesise that vascular disruption and concomitant release of monomeric-C-reactive protein within the brain tissue could exacerbate ongoing neurological damage via stimulation of neuro-inflammation and from direct consequences of its action on both neuronal and vascular cells.