"Pyrimethamine and Proguanil Resistance-Conferring Key Mutations in Dihydrofolate Reductase Gene of Plasmodium falciparum Isolates from Iran"
Using mutation specific PCR assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 Plasmodium falciparum isolates of malarial patients from southern areas of Iran, showed 4 different situations: iwild type (108-Ser) ii-mutant type (108-Thr) iii-mutan...
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| Format: | Book |
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Tehran University of Medical Sciences,
2003-10-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_b17a6be0ac79469ca69ffec3a8f39a1d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a AA Eskandarian |e author |
| 700 | 1 | 0 | |a H Keshavarz |e author |
| 700 | 1 | 0 | |a F Mahboudi |e author |
| 245 | 0 | 0 | |a "Pyrimethamine and Proguanil Resistance-Conferring Key Mutations in Dihydrofolate Reductase Gene of Plasmodium falciparum Isolates from Iran" |
| 260 | |b Tehran University of Medical Sciences, |c 2003-10-01T00:00:00Z. | ||
| 500 | |a 2251-6085 | ||
| 520 | |a Using mutation specific PCR assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 Plasmodium falciparum isolates of malarial patients from southern areas of Iran, showed 4 different situations: iwild type (108-Ser) ii-mutant type (108-Thr) iii-mutant type (108-Asn) and iv-mixed wild and mutant type (108-Ser+Thr) with frequency of 58(82.8%), 2(2.9%), 8(11.4%) and 2(2.9%) respectively. Many studies have demonstrated that mutations in position 108 have key role for emerging resistance to anti-folate drugs in falciparum malaria so, the resistance to pyrimethamine and proguanil, presents in Plasmodium falciparum isolates from malarious endemic regions of Iran. | ||
| 546 | |a EN | ||
| 690 | |a Plasmodium falciparum | ||
| 690 | |a Drug resistance | ||
| 690 | |a Pyrimethamine | ||
| 690 | |a Proguanil | ||
| 690 | |a Public aspects of medicine | ||
| 690 | |a RA1-1270 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Iranian Journal of Public Health, Vol 32, Iss 4, Pp 8-12 (2003) | |
| 787 | 0 | |n http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/145.pdf&manuscript_id=145 | |
| 787 | 0 | |n https://doaj.org/toc/2251-6085 | |
| 856 | 4 | 1 | |u https://doaj.org/article/b17a6be0ac79469ca69ffec3a8f39a1d |z Connect to this object online. |