Alternative splicing perturbation landscape identifies RNA binding proteins as potential therapeutic targets in cancer

• Main Authors: Junyi Li (Author), Tao Pan (Author), Liuxin Chen (Author), Qi Wang (Author), Zhenghong Chang (Author), Weiwei Zhou (Author), Xinhui Li (Author), Gang Xu (Author), Xia Li (Author), Yongsheng Li (Author), Yunpeng Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alternative splicing (AS) plays an important role in gene regulation, and AS perturbations are frequently observed in cancer. RNA binding protein (RBP) is one of the molecular determinants of AS, and perturbations in RBP-gene network activity are causally associated with cancer development. Here, we...