Impact of the homozygous mutation in Nudix hydrolase 15 on myelosuppression with 6-mercaptopurine in a European girl with acute lymphoblastic leukemia: a case report

• Main Authors: Laura Elena Pineda-Lancheros (Author), María del Mar Sánchez-Suárez (Author), Luciana María Marangoni-Iglecias (Author), Ricardo García-Fumero (Author), Susana Rojo-Tolosa (Author), Noelia Moreno-Toro (Author)
• Format: Book
• Published: Facultad de Farmacia, Universidad de Granada, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A 6-year-old girl diagnosed with intermediate-risk acute lymphoblastic leukemia (ALL) presented with severe myelotoxicity and multiple infections during phase IB induction treatment with 6-mercaptopurine (6-MP). In the subsequent treatment phases, which included 6-MP, the patient continued...