Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation

• Main Authors: Martina Durcik (Author), Žiga Skok (Author), Janez Ilaš (Author), Nace Zidar (Author), Anamarija Zega (Author), Petra Éva Szili (Author), Gábor Draskovits (Author), Tamás Révész (Author), Danijel Kikelj (Author), Akos Nyerges (Author), Csaba Pál (Author), Lucija Peterlin Mašič (Author), Tihomir Tomašič (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can be inhibited at their catalytic sites or at their...