Disulfiram inhibits liver fibrosis in rats by suppressing hepatic stellate cell activation and viability

• Main Authors: Xiao-Mei Yang (Author), Zheng Wu (Author), Xiaoqi Wang (Author), Yaoqi Zhou (Author), Lei Zhu (Author), Dongxue Li (Author), Hui-Zhen Nie (Author), Ya-Hui Wang (Author), Jun Li (Author), Xueyun Ma (Author)
• Format: Book
• Published: BMC, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Liver fibrosis is a wound-healing response to chronic injury, featuring with excess accumulation of extracellular matrix secreted by the activated hepatic stellate cells (HSC). Disulfiram (DSF), also known as Antabuse, has been used for the treatment of alcohol addiction and subs...