Contribution of Active and Inactive States of the Human 5-HT4d Receptor to the Functional Activities of 5-HT4-Receptor Agonists

• Main Authors: Tadayoshi Mikami (Author), Hiromi Sugimoto (Author), Rie Naganeo (Author), Takashi Ohmi (Author), Toshiyuki Saito (Author), Hiroyuki Eda (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, binding affinities of 5-hydroxytryptamine-4 (5-HT4) ligands for the human 5-HT4d receptor were determined using the agonist [3H]5-HT and the selective 5-HT4 antagonist [3H]GR113,808. We also compared the affinity differences between [3H]5-HT binding (KH) and [3H]GR113,808 bindi...