Formulation of Chewable Tablets Containing Carbamazepine-β-cyclodextrin Inclusion Complex and F-Melt Disintegration Excipient. The Mathematical Modeling of the Release Kinetics of Carbamazepine

• Main Authors: Adina Magdalena Musuc (Author), Valentina Anuta (Author), Irina Atkinson (Author), Iulian Sarbu (Author), Vlad Tudor Popa (Author), Cornel Munteanu (Author), Constantin Mircioiu (Author), Emma Adriana Ozon (Author), George Mihai Nitulescu (Author), Mirela Adriana Mitu (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Due to its low solubility, carbamazepine (CBZ) exhibits slow and incomplete release in the gastrointestinal tract and, hence, variable pharmacokinetics and pharmacodynamic effect. Lots of methods have been devised to improve its solubility, the large number of proposed solutions being a sign that th...