Use of Blood Lipid Indicators as a Screening Tool of Insulin Resistance among Individuals in Low-Income Country Sides of China: A Multiethnic Region Study

Objective. This study is aimed at evaluating the diagnostic value of blood lipid indicators (BLIs) for insulin resistance (IR) among major ethnic groups in Xinjiang, China, to identify the most valuable indicators and appropriate cut-off points for each ethnic group and to lay the foundation for the...

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Main Authors: Yi-Zhong Yan (Author), Jia-Ning Fan (Author), Jia-Ming Liu (Author), Yun-hua Hu (Author), Jiao-Long Ma (Author), Jia He (Author), Heng Guo (Author), Xiang-hui Zhang (Author), Xin-ping Wang (Author), Shu-gang Li (Author), Shu-Xia Guo (Author)
Format: Book
Published: Hindawi Limited, 2019-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Yi-Zhong Yan  |e author 
700 1 0 |a Jia-Ning Fan  |e author 
700 1 0 |a Jia-Ming Liu  |e author 
700 1 0 |a Yun-hua Hu  |e author 
700 1 0 |a Jiao-Long Ma  |e author 
700 1 0 |a Jia He  |e author 
700 1 0 |a Heng Guo  |e author 
700 1 0 |a Xiang-hui Zhang  |e author 
700 1 0 |a Xin-ping Wang  |e author 
700 1 0 |a Shu-gang Li  |e author 
700 1 0 |a Shu-Xia Guo  |e author 
245 0 0 |a Use of Blood Lipid Indicators as a Screening Tool of Insulin Resistance among Individuals in Low-Income Country Sides of China: A Multiethnic Region Study 
260 |b Hindawi Limited,   |c 2019-01-01T00:00:00Z. 
500 |a 0962-9351 
500 |a 1466-1861 
500 |a 10.1155/2019/3592620 
520 |a Objective. This study is aimed at evaluating the diagnostic value of blood lipid indicators (BLIs) for insulin resistance (IR) among major ethnic groups in Xinjiang, China, to identify the most valuable indicators and appropriate cut-off points for each ethnic group and to lay the foundation for the early detection, diagnosis, and treatment of metabolic diseases in remote rural areas. Methods. Overall, 418 Uygurs, 331 Kazakhs, and 220 Hans were randomly included in our study. The homeostasis model assessment was the gold standard for identifying IR. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value, and the nomogram was utilized to analyze the predictive value. The size of the area under the curve (AUC) reflected the accuracy of screening and prediction. Results. Differences in races were observed in terms of IR and BLIs, and the Kazakhs had the highest IR level at 5.27 mmol/L. The correlation between IR and BLIs differed among the three races. For the Kazakhs and Hans, all BLIs, except total cholesterol (TC), were correlated to IR. However, for the Uygurs, only the triglyceride (TG) level, TG/high-density lipoprotein cholesterol (HDL-C) ratio, and TC/HDL-C ratio were associated with IR. After further adjustment of confounding factors, these indicators were still correlated to IR. BLIs that independently correlated to IR in the three nationalities had a certain diagnostic value for IR. In terms of the AUC size, the TG level was the highest in Uygurs, the TG/HDL-C ratio was the highest for Kazakhs and Hans, and the corresponding best cut-off points for IR were 1.515, 1.230, and 1.495 mmol/L, respectively. In addition, for each race, when the indicators with a certain diagnostic value were combined, the diagnostic value for IR was higher. Conclusion. BLIs had a certain diagnostic value for IR and could be used as a screening tool for IR among Uygurs, Kazakhs, and Hans in Xinjiang. These findings are extremely important for the prevention and treatment of IR and metabolic diseases in remote rural areas. 
546 |a EN 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Mediators of Inflammation, Vol 2019 (2019) 
787 0 |n http://dx.doi.org/10.1155/2019/3592620 
787 0 |n https://doaj.org/toc/0962-9351 
787 0 |n https://doaj.org/toc/1466-1861 
856 4 1 |u https://doaj.org/article/b31a860cf6d344d3bb7c8dc5bef33a0d  |z Connect to this object online.