IgA vasculitis nephritis (Schönlein-Henoch purpura with nephritis) following COVID-19 vaccination

• Main Authors: Leila Mahmoodnia (Author), Shahin Asgari Savadjani (Author), Leila Mostafavi (Author), Setayesh Sotoudehnia Korani (Author), Fatemeh Mohammad Alizadeh (Author), Mahshid Sadat Chenarani Moghadam (Author), Hamid Reza Jahantigh (Author), Sina Neshat (Author), Ali Shirbacheh (Author), Jyoti Baharani (Author), Rohollah Masomi (Author), Zahra Golestani Hotkani (Author)
• Format: Book
• Published: Society of Diabetic Nephropathy Prevention, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

IgA vasculitis nephritis (Schönlein-Henoch purpura nephritis) is an autoimmune circumstance characterized by palpable purpura involving the lower limbs, arthralgia, abdominal pain and kidney involvement. It is possible that a cytokine storm following coronavirus disease 2019 (COVID-19) could lead to an immunological dysregulation responsible for IgA vasculitis nephritis in these cases. Reactivation or first onset of IgA vasculitis nephritis is uncommon; however, there have been increasing reports of this disease, as a complication of COVID-19 vaccination. It is possible that COVID-19 mRNA vaccination may trigger several auto-inflammatory and autoimmune cascades. Previous research has shown that Toll-like receptors play a role in the development of IgA vasculitis nephritis. Following injection of a COVID-19 mRNA vaccine, the uptake of double-stranded RNA by-products will trigger Toll-like receptors, leading to a series of intracellular cascades starting an innate immunity-driven process of cell-mediated and humoral- mediated immunity.

Item Description

2251-8363
2251-8819
10.34172/jnp.2023.21447