Design and synthesis of naphthalimide group-bearing thioglycosides as novel β-N-acetylhexosaminidases inhibitors

• Main Authors: Shengqiang Shen (Author), Wei Chen (Author), Lili Dong (Author), Qing Yang (Author), Huizhe Lu (Author), Jianjun Zhang (Author)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

GH20 human β-N-acetylhexosaminidases (hsHex) and GH84 human O-GlcNAcase (hOGA) are involved in numerous pathological processes and emerged as promising targets for drug discovery. Based on the catalytic mechanism and structure of the catalytic domains of these β-N-acetylhexosaminidases, a series of...