The Contribution of Gi/o Protein to Opioid Antinociception in an Oxaliplatin-Induced Neuropathy Rat Model

• Main Authors: Tomoe Kanbara (Author), Atsushi Nakamura (Author), Keiko Takasu (Author), Koichi Ogawa (Author), Masahiro Shibasaki (Author), Tomohisa Mori (Author), Tsutomu Suzuki (Author), Minoru Hasegawa (Author), Gaku Sakaguchi (Author), Toshiyuki Kanemasa (Author)
• Format: Book
• Published: Elsevier, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Oxaliplatin is a chemotherapeutic agent that induces chronic refractory neuropathy. To determine whether opioids effectively relieve this chronic neuropathy, we investigated the efficacies of morphine, oxycodone, and fentanyl, and the mechanisms underlying opioid antinociception, in oxali...