miRNAs as Therapeutic Tools and Biomarkers for Prostate Cancer

Prostate cancer (PCa) is the fifth cause of tumor-related deaths in man worldwide. Despite the considerable improvement in the clinical management of PCa, several limitations emerged both in the screening for early diagnosis and in the medical treatment. The use of prostate-specific antigen (PSA)-ba...

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Κύριοι συγγραφείς: Noemi Arrighetti (Συγγραφέας), Giovanni Luca Beretta (Συγγραφέας)
Μορφή: Βιβλίο
Έκδοση: MDPI AG, 2021-03-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Noemi Arrighetti  |e author 
700 1 0 |a Giovanni Luca Beretta  |e author 
245 0 0 |a miRNAs as Therapeutic Tools and Biomarkers for Prostate Cancer 
260 |b MDPI AG,   |c 2021-03-01T00:00:00Z. 
500 |a 10.3390/pharmaceutics13030380 
500 |a 1999-4923 
520 |a Prostate cancer (PCa) is the fifth cause of tumor-related deaths in man worldwide. Despite the considerable improvement in the clinical management of PCa, several limitations emerged both in the screening for early diagnosis and in the medical treatment. The use of prostate-specific antigen (PSA)-based screening resulted in patients' overtreatment and the standard therapy of patients suffering from locally advanced/metastatic tumors (e.g., radical prostatectomy, radiotherapy, and androgen deprivation therapy) showed time-limited efficacy with patients undergoing progression toward the lethal metastatic castration-resistant PCa (mCRPC). Although valuable alternative therapeutic options have been recently proposed (e.g., docetaxel, cabazitaxel, abiraterone, enzalutamide, and sipuleucel-T), mCRPC remains incurable. Based on this background, there is an urgent need to identify new and more accurate prostate-specific biomarkers for PCa diagnosis and prognosis and to develop innovative medical approaches to counteract mCRPC. In this context, microRNA (miRNAs) emerged as potential biomarkers in prostate tissues and biological fluids and appeared to be promising therapeutic targets/tools for cancer therapy. Here we overview the recent literature and summarize the achievements of using miRNAs as biomarkers and therapeutic targets/tools for fighting PCa. 
546 |a EN 
690 |a prostate cancer 
690 |a miRNA 
690 |a nanodelivery 
690 |a metastatic castration-resistant prostate cancer 
690 |a biomarkers 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Pharmaceutics, Vol 13, Iss 3, p 380 (2021) 
787 0 |n https://www.mdpi.com/1999-4923/13/3/380 
787 0 |n https://doaj.org/toc/1999-4923 
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