Copy number variation of urine exfoliated cells by low-coverage whole genome sequencing for diagnosis of prostate adenocarcinoma: a prospective cohort study

• Main Authors: Youyan Guan (Author), Xiaobing Wang (Author), Kaopeng Guan (Author), Dong Wang (Author), Xingang Bi (Author), Zhendong Xiao (Author), Zejun Xiao (Author), Xingli Shan (Author), Linjun Hu (Author), Jianhui Ma (Author), Changling Li (Author), Yong Zhang (Author), Jianzhong Shou (Author), Baiyun Wang (Author), Ziliang Qian (Author), Nianzeng Xing (Author)
• Format: Book
• Published: BMC, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Non-invasive, especially the urine-based diagnosis of prostate cancer (PCa) remains challenging. Although prostate cancer antigen (PSA) is widely used in prostate cancer screening, the false positives may result in unnecessary invasive procedures. PSA elevated patients are triage...