Effects of Supplementation with the Standardized Extract of Saffron (affron^®) on the Kynurenine Pathway and Melatonin Synthesis in Rats

• Main Authors: Mario De la Fuente Muñoz (Author), Marta Román-Carmena (Author), Sara Amor (Author), Ángel Luís García-Villalón (Author), Alberto E. Espinel (Author), Daniel González-Hedström (Author), Miriam Granado García (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melatonin is a hormone that regulates sleep-wake cycles and is mainly synthesized in the pineal gland from tryptophan after its conversion into serotonin. Under normal conditions, less than 5% of tryptophan is reserved for the synthesis of serotonin and melatonin. The remaining 95% is metabolized in...