<i>Thymus zygis</i> Essential Oil: Phytochemical Characterization, Bioactivity Evaluation and Synergistic Effect with Antibiotics against <i>Staphylococcus aureus</i>
<i>Staphylococcus aureus</i> is a nosocomial bacterium causing different infectious diseases, ranging from skin and soft-tissue infections to more serious and life-threatening infections such as sepsis, meningitis and endocarditis, which may be exacerbated by antibiotic resistance. Plant...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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MDPI AG,
2022-01-01T00:00:00Z.
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| Summary: | <i>Staphylococcus aureus</i> is a nosocomial bacterium causing different infectious diseases, ranging from skin and soft-tissue infections to more serious and life-threatening infections such as sepsis, meningitis and endocarditis, which may be exacerbated by antibiotic resistance. Plant products may be seen as an alternative as antibacterial agents, namely, against <i>S. aureus</i>. Thus, the aim of this work was to characterize the chemical composition and evaluate the bioactive properties of the <i>T. zygis</i> essential oil (EO), with a focus on antimicrobial activity against <i>S. aureus</i>. Gas chromatography coupled with mass spectrometry was used to assess the chemical composition of the <i>T. zygis</i> EO, and the antioxidant activity was evaluated using the DPPH method and β-carotene-bleaching assay. The antimicrobial activity against <i>S. aureus</i> strains, the interaction with different antibiotics and the attenuation of this bacterium's virulence were evaluated. The <i>T. zygis</i> EO showed antioxidant activity acting through two different mechanisms and antibacterial activity against <i>S. aureus</i>, with antibiofilm and antihaemolytic properties. This EO also demonstrated synergistic or additive interactions in combination with ampicillin, ciprofloxacin or vancomycin against <i>S. aureus</i> strains and, in some cases, changed the antibiotic-resistance phenotype from resistant to susceptible. Therefore, the present work demonstrates the good bioactive properties of the EO of <i>T. zygis,</i> mainly the antimicrobial activity against <i>S. aureus</i>, revealing its potential to be used as an antibacterial agent. |
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| Item Description: | 10.3390/antibiotics11020146 2079-6382 |