The <it>APOA5 </it>Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides
<p>Abstract</p> <p>Background</p> <p>The goal of the present study was to assess the effect of genetic variability at the APOA5/A4/C3/A1 cluster locus on the risk of metabolic syndrome.</p> <p>Methods</p> <p>The <it>APOA5 </it>Ser19Tr...
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2008-09-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_b4c40d092d784d338f0dbc9d81c9b8e7 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ferrières Jean |e author |
| 700 | 1 | 0 | |a Bingham Annie |e author |
| 700 | 1 | 0 | |a Arveiler Dominique |e author |
| 700 | 1 | 0 | |a Ruidavets Jean-Bernard |e author |
| 700 | 1 | 0 | |a Ducimetière Pierre |e author |
| 700 | 1 | 0 | |a Wagner Aline |e author |
| 700 | 1 | 0 | |a Cottel Dominique |e author |
| 700 | 1 | 0 | |a Dallongeville Jean |e author |
| 700 | 1 | 0 | |a Amouyel Philippe |e author |
| 700 | 1 | 0 | |a Meirhaeghe Aline |e author |
| 245 | 0 | 0 | |a The <it>APOA5 </it>Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides |
| 260 | |b BMC, |c 2008-09-01T00:00:00Z. | ||
| 500 | |a 10.1186/1471-2350-9-84 | ||
| 500 | |a 1471-2350 | ||
| 520 | |a <p>Abstract</p> <p>Background</p> <p>The goal of the present study was to assess the effect of genetic variability at the APOA5/A4/C3/A1 cluster locus on the risk of metabolic syndrome.</p> <p>Methods</p> <p>The <it>APOA5 </it>Ser19Trp, <it>APOA5 </it>-12,238T>C, <it>APOA4 </it>Thr347Ser, <it>APOC3 </it>-482C>T and <it>APOC3 </it>3238C>G (<it>Sst</it>I) polymorphisms were analyzed in a representative population sample of 3138 men and women from France, including 932 individuals with metabolic syndrome and 2206 without metabolic syndrome, as defined by the NCEP criteria.</p> <p>Results</p> <p>Compared with homozygotes for the common allele, the odds ratio (OR) [95% CI] for metabolic syndrome was 1.30 [1.03-1.66] (<it>p </it>= 0.03) for <it>APOA5 </it>Trp19 carriers, 0.81 [0.69-0.95] (<it>p </it>= 0.01) for <it>APOA5 </it>-12,238C carriers and 0.84 [0.70-0.99] (<it>p </it>= 0.04) for <it>APOA4 </it>Ser347 carriers. Adjustment for plasma triglycerides, (but not for waist girth, HDL, blood pressure or glycemia - the other components of metabolic syndrome) abolished these associations and suggests that triglyceride levels explain the association with metabolic syndrome. There was no association between the <it>APOC3 </it>-482C>T or <it>APOC3 </it>3238C>G polymorphisms and metabolic syndrome. The decreased risk of metabolic syndrome observed in <it>APOA5 </it>-12,238C and <it>APOA4 </it>Ser347 carriers merely reflected the fact that the <it>APOA5 </it>Trp19 allele was in negative linkage disequilibrium with the common alleles of <it>APOA5 </it>-12,238T>C and <it>APOA4 </it>Thr347Ser polymorphisms.</p> <p>Conclusion</p> <p>The <it>APOA5 </it>Trp19 allele increased susceptibility to metabolic syndrome via its impact on plasma triglyceride levels.</p> | ||
| 546 | |a EN | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 690 | |a Genetics | ||
| 690 | |a QH426-470 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n BMC Medical Genetics, Vol 9, Iss 1, p 84 (2008) | |
| 787 | 0 | |n http://www.biomedcentral.com/1471-2350/9/84 | |
| 787 | 0 | |n https://doaj.org/toc/1471-2350 | |
| 856 | 4 | 1 | |u https://doaj.org/article/b4c40d092d784d338f0dbc9d81c9b8e7 |z Connect to this object online. |