Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients

• 主要な著者: Joanna Bartosińska (著者), Ewelina Zakrzewska (著者), Dorota Raczkiewicz (著者), Joanna Purkot (著者), Anna Michalak-Stoma (著者), Małgorzata Kowal (著者), Dorota Krasowska (著者), Grażyna Chodorowska (著者), Krzysztof Giannopoulos (著者)
• フォーマット: 図書
• 出版事項: Hindawi Limited, 2017-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.
• Notes: 0962-9351; 1466-1861; 10.1155/2017/5385102
• Keywords: Pathology; RB1-214
• Source: Mediators of Inflammation, Vol 2017 (2017)

Psoriasis is a chronic inflammatory disease mediated by T cell immunity. Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. The aim of the study was to compare the expression of PD-1 on the peripheral T cells between psoriatic patients and healthy controls. The study included 75 psoriatic patients and 52 healthy volunteers. The percentages and absolute numbers of CD3+, CD4+, CD8+, CD4+PD-1+, and CD8+PD-1+ T cells were analyzed using flow cytometry. The absolute numbers and percentages of CD4+PD-1+ and CD8+PD-1+ T cells were significantly decreased in the psoriatic patients in comparison with the control group. No significant correlations were found between the absolute numbers and percentages of CD4+PD-1+ or CD8+PD-1+ T cells and clinical characteristics of psoriasis. Decreased PD-1 expression on the T cells may be responsible for impaired negative regulation of immune response in psoriasis pathogenesis.