Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury

• Main Authors: Nicole Labusek (Author), Yanis Mouloud (Author), Christian Köster (Author), Eva Diesterbeck (Author), Tobias Tertel (Author), Constanze Wiek (Author), Helmut Hanenberg (Author), Peter A. Horn (Author), Ursula Felderhoff-Müser (Author), Ivo Bendix (Author), Bernd Giebel (Author), Josephine Herz (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Human mesenchymal stromal cell (MSC)-derived extracellular vesicles (EV) revealed neuroprotective potentials in various brain injury models, including neonatal encephalopathy caused by hypoxia-ischemia (HI). However, for clinical translation of an MSC-EV therapy, scaled manufactu...