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Infection Sources and <i>Klebsiella pneumoniae</i> Antibiotic Susceptibilities in Endogenous <i>Klebsiella</i> Endophthalmitis

Endogenous endophthalmitis is an uncommon intraocular infection with potentially devastating consequences on vision. <i>Klebsiella pneumoniae</i> is highly prevalent in East Asian countries, with an increasing incidence recently worldwide. This retrospective study investigates infection...

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Main Authors: Kuan-Jen Chen (Author), Yen-Po Chen (Author), Yi-Hsing Chen (Author), Laura Liu (Author), Nan-Kai Wang (Author), An-Ning Chao (Author), Wei-Chi Wu (Author), Yih-Shiou Hwang (Author), Hung-Da Chou (Author), Eugene Yu-Chuan Kang (Author), Yen-Ting Chen (Author), Ming-Hui Sun (Author), Chi-Chun Lai (Author)
Format: Book
Published: MDPI AG, 2022-06-01T00:00:00Z.
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Summary:Endogenous endophthalmitis is an uncommon intraocular infection with potentially devastating consequences on vision. <i>Klebsiella pneumoniae</i> is highly prevalent in East Asian countries, with an increasing incidence recently worldwide. This retrospective study investigates infection sources and antibiotic susceptibilities of <i>K. pneumoniae</i> in patients with endogenous <i>K. pneumoniae</i> endophthalmitis (EKE) in Northern Taiwan. One hundred and fifty-seven patients with EKE were reviewed between January 1996 and April 2019. Pyogenic liver abscess (120/157, 76.4%) was the most common infection source, followed by pneumonia (13, 8.3%), urinary tract infection (7, 4.5%), and intravenous drug use (4, 2.5%). Bilateral involvement was identified in 12.1% (19/157) of patients, especially in patients with pyogenic liver abscess (16/120, 13.3%), pneumonia (2/13, 15.4%), and urinary tract infection (1/7, 14.3%). The antibiotic susceptibility rates were 98.1%, 92.5%, 97.5%, 96.8%, 100%, 99.3%, and 100% for amikacin, cefuroxime, ceftazidime, ceftriaxone, carbapenems, ciprofloxacin, and levofloxacin, respectively. Four extended-spectrum β-lactamase-producing multidrug-resistant (MDR) <i>K. pneumoniae</i> isolates were identified. In conclusion, pyogenic liver abscess was the major infection source in EKE. In addition, <i>K. pneumoniae</i> was still highly susceptible to ceftazidime and amikacin, and the MDR <i>K. pneumoniae</i> isolates were not common in EKE.
Item Description:10.3390/antibiotics11070866
2079-6382

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