Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats

• Main Authors: Kai-Kai Zhang (Author), Hui Wang (Author), Dong Qu (Author), Li-Jian Chen (Author), Li-Bin Wang (Author), Jia-Hao Li (Author), Jia-Li Liu (Author), Ling-Ling Xu (Author), Jamie Still Yoshida (Author), Jing-Tao Xu (Author), Xiao-Li Xie (Author), Dong-Ri Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Misuse of the psychostimulant methamphetamine (METH) could induce serious hepatotoxicity. Our previous study revealed the effects of luteolin on alleviating METH-induced hepatotoxicity, however, the detailed mechanisms have not been elucidated. In this study, rats were orally pretreated with 100 mg/...