Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway

• Main Authors: Qing Rao (Author), Kaiqiang Xie (Author), Krishnapriya M. Varier (Author), Lei Huang (Author), Jingrui Song (Author), Jue Yang (Author), Jianfei Qiu (Author), Yubing Huang (Author), Yan Li (Author), Babu Gajendran (Author), Yanmei Li (Author), Sheng Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic myeloid leukemia (CML) accounts for a major cause of death in adult leukemia patients due to mutations or other reasons for dysfunction in the ABL proto-oncogene. The ubiquitous BCR-ABL expression stimulates CML by activating CDK1 and cyclin B1, promoting pro-apoptotic, and inhibiting antiap...