Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation
Quantitative pharmacology brings important advantages in the design and conduct of pediatric clinical trials. Herein, we demonstrate the application of a model-based approach to select doses and pharmacokinetic sampling scenarios for the clinical evaluation of a novel oral suspension of spironolacto...
Saved in:
Main Authors: | Manasa Tatipalli (Author), Vijay Kumar Siripuram (Author), Tao Long (Author), Diana Shuster (Author), Galina Bernstein (Author), Pierre Martineau (Author), Kim A. Cook (Author), Rodrigo Cristofoletti (Author), Stephan Schmidt (Author), Valvanera Vozmediano (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2021-06-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology-What's Next?-Joining Mechanistic and Epidemiological Approaches
by: Stephan Schmidt, et al.
Published: (2019) -
In Vitro Pharmacokinetic/Pharmacodynamic Modelling and Simulation of Amphotericin B against <i>Candida auris</i>
by: Unai Caballero, et al.
Published: (2021) -
Leveraging Physiologically Based Modelling to Provide Insights on the Absorption of Paliperidone Extended-Release Formulation under Fed and Fasting Conditions
by: Saima Subhani, et al.
Published: (2023) -
Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples
by: Ricardo Ferreira-Nunes, et al.
Published: (2023) -
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim
by: Sumit Basu, et al.
Published: (2020)