Condition of pro-oxidant system in guinea pigs' bronchi in experimental allergic alveolitis development and their correction with thiotriazolin
Exogenic allergic alveolitis has been ascribed to multiple inhaled antigens found in a large variety of environmental settings. The immune mechanisms leading to this deases development are still incompletely understood. Initially, believed to be a classes III and IV immune response, we now have a cl...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Published: |
Kazimierz Wielki University,
2017-06-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Exogenic allergic alveolitis has been ascribed to multiple inhaled antigens found in a large variety of environmental settings. The immune mechanisms leading to this deases development are still incompletely understood. Initially, believed to be a classes III and IV immune response, we now have a clearer understanding of the complex inflammatory events involved. These include the release of pro inflammatory cytokines and a decrease in the immune control mechanisms via surfactant, dendritic and T-regulatory cells. Free radicals and reactive oxygen species could play a major role in the pathophysiology of allergic alveolitis . Despite the improved understanding, the treatment and outcome of this pathology have not known enough. This work determinate on accumulation of lipid peroxidaton products in the animals` bronchi during experimental allergic alveolitis and corrective effect of antioxidant-thiotriazolin on these indicators. |
|---|---|
| Item Description: | 2391-8306 |