In Vitro Safety, Off-Target and Bioavailability Profile of the Antiviral Compound Silvestrol

• Main Authors: Susanne Schiffmann (Author), Sandra Gunne (Author), Thomas Ulshöfer (Author), Marina Henke (Author), Luise A. Roser (Author), Ann-Kathrin Schneider (Author), Jindrich Cinatl (Author), Dominique Thomas (Author), Yannick Schreiber (Author), Pia Viktoria Wagner (Author), Arnold Grünweller (Author), Michael J. Parnham (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We characterized the in vitro safety and bioavailability profile of silvestrol, a compound effective against various viruses, such as corona- and Ebolaviruses, with an EC₅₀ value of about 5 nM. The cytotoxic profile of silvestrol was assessed in various cancer cell lines, as w...