Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes

• मुख्य लेखकों: Yolanda Alvarez (लेखक), Isela Valera (लेखक), Cristina Municio (लेखक), Etzel Hugo (लेखक), Francisco Padrón (लेखक), Lydia Blanco (लेखक), Mario Rodríguez (लेखक), Nieves Fernández (लेखक), Mariano Sánchez Crespo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Hindawi Limited, 2010-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.
• Notes: 0962-9351; 1466-1861; 10.1155/2010/201929
• Keywords: Pathology; RB1-214
• Source: Mediators of Inflammation, Vol 2010 (2010)

The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it induced the production of PGE2, PGD2, and several cytokines including a robust IL-10 response. Zymosan activated κB-binding activity, but inhibition of NF-κB was associated with enhanced IL-10 production. In contrast, treatments acting on CREB (CRE binding protein), including PGE2, showed a direct correlation between CREB activation and IL-10 production. Therefore, in dendritic cells zymosan induces il10 transcription by a CRE-dependent mechanism that involves autocrine secretion of PGE2, thus unraveling a functional cooperation between eicosanoid production and cytokine production.