Angpt2 Induces Mesangial Cell Apoptosis through the MicroRNA-33-5p-SOCS5 Loop in Diabetic Nephropathy

• Main Authors: Yi-Chun Tsai (Author), Po-Lin Kuo (Author), Wei-Wen Hung (Author), Ling-Yu Wu (Author), Ping-Hsun Wu (Author), Wei-An Chang (Author), Mei-Chuan Kuo (Author), Ya-Ling Hsu (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Mesangial cell (MC) loss is correlated with worsening renal function in DN. Disturbance of angiopoietin (Angpt)/Tie ligand-receptor system causes inflammation and abnormal angiogenesis. This association between elevated circu...