Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis

• Principais autores: Francesca De Giorgio (Autor), Cheryl Maduro (Autor), Elizabeth M. C. Fisher (Autor), Abraham Acevedo-Arozena (Autor)
• Formato: Livro
• Publicado em: The Company of Biologists, 2019-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

A wide range of genetic mouse models is available to help researchers dissect human disease mechanisms. Each type of model has its own distinctive characteristics arising from the nature of the introduced mutation, as well as from the specific changes to the gene of interest. Here, we review the cur...