Goodpasture\'s syndrome in pregnancy without renal involvement: A case report

• Main Authors: Taghi Riahi (Author), Laily Najafi (Author), Omolbanin Asadi Ghadikolaei (Author), Mohammad Hadi Tajik Jalayeri (Author)
• Format: Book
• Published: Babol University of Medical Sciences, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2008-6164; 2008-6172
• Keywords: goodpasture's syndrome; pregnancy; respiratory failure; renal involvement; case report.; Internal medicine; RC31-1245
• Source: Caspian Journal of Internal Medicine, Vol 13, Iss 2, Pp 442-446 (2022)

Background: Goodpasture syndrome (GPS) rarely affects parturients which may quickly result in severe pulmonary and renal damage with significant fetomaternal morbidity. Case Presentation: A 35-year-old white multiparous lady, presented with acute progressive respiratory failure at 32th gestational age. She had fever, cough, severe dyspnea and lately hemoptysis and severe hypoxia with bilateral alveolar opacity in chest imaging, with no response to broad spectrum antibiotic. GPS diagnosis was confirmed by high anti- glomerular basement membrane (anti GBM) titer, without the similar history in the past parities. High dose intravenous methylprednisolone ended to dramatic clinical response. She was maintained on glucocorticoids for five weeks before the successful delivery of a live healthy fetus at 39 Weeks. Conclusion: This study demonstrated a successful pregnancy outcome which was achieved in the present GPS parturient with a careful antepartum care involving maternal-fetal status by serial pulmonary, renal monitoring and special treatment of disease.