A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models

• Main Authors: Rosamaria Lappano (Author), Camillo Rosano (Author), Assunta Pisano (Author), Maria Francesca Santolla (Author), Ernestina Marianna De Francesco (Author), Paola De Marco (Author), Vincenza Dolce (Author), Marco Ponassi (Author), Lamberto Felli (Author), Grazia Cafeo (Author), Franz Heinrich Kohnke (Author), Sergio Abonante (Author), Marcello Maggiolini (Author)
• Format: Book
• Published: The Company of Biologists, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Estrogens regulate numerous pathophysiological processes, mainly by binding to and activating estrogen receptor (ER)α and ERβ. Increasing amounts of evidence have recently demonstrated that G-protein coupled receptor 30 (GPR30; also known as GPER) is also involved in diverse biological responses to...