Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series

Abstract Background: Some women represent the inability to respond to endogenous and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm injection cycles leading to the follicular developmental arrest. The women with resistant ovaries could benefit from in vitro maturation....

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Main Authors: Maryam Eftekhar (Author), Banafsheh Mohammadi (Author), Nasim Tabibnejad (Author), Mohammad Hossein Razi (Author)
Format: Book
Published: Shahid Sadoughi University of Medical Sciences, 2021-06-01T00:00:00Z.
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001 doaj_b6eb1cb4061e473d8f19ee3fa9f7a49b
042 |a dc 
100 1 0 |a Maryam Eftekhar  |e author 
700 1 0 |a Banafsheh Mohammadi  |e author 
700 1 0 |a Nasim Tabibnejad  |e author 
700 1 0 |a Mohammad Hossein Razi  |e author 
245 0 0 |a Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series 
260 |b Shahid Sadoughi University of Medical Sciences,   |c 2021-06-01T00:00:00Z. 
500 |a 2476-4108 
500 |a 2476-3772 
500 |a 10.18502/ijrm.v19i6.9378 
520 |a Abstract Background: Some women represent the inability to respond to endogenous and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm injection cycles leading to the follicular developmental arrest. The women with resistant ovaries could benefit from in vitro maturation. Case: This case-series presents pregnancies resulting from initially scheduled conventional in vitro fertilization which led to arrested cycles because of resistant ovary syndrome. The protocol was changed to early oocyte triggering for 15 women due to the small follicles ≤ 12 mm in diameter on day 15 after stimulation with high doses of exogenous gonadotrophins instead of cycle cancellation. Germinal vesicle and metaphase I oocytes that were retrieved from follicles were matured in vitro and inseminated by intracytoplasmic sperm injection. Twenty formed embryos were transferred on day 3 after oocyte retrieval. This resulted in a 30.76% chemical pregnancy out of which no abortion occurred. Therefore, we reported a 30.76% singleton ongoing pregnancy. Conclusion: It seems that early oocyte triggering followed by in vitro maturation may be considered as a good modality in women experiencing follicular resistance to gonadotropins. These cycles can be rescued from cancellation with satisfactory clinical outcomes. 
546 |a EN 
690 |a arrested stimulation cycle, early oocyte triggering, in vitro maturation, clinical outcome. 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
690 |a Reproduction 
690 |a QH471-489 
655 7 |a article  |2 local 
786 0 |n International Journal of Reproductive BioMedicine, Vol 19, Iss 6, Pp 569-574 (2021) 
787 0 |n https://doi.org/10.18502/ijrm.v19i6.9378 
787 0 |n https://doaj.org/toc/2476-4108 
787 0 |n https://doaj.org/toc/2476-3772 
856 4 1 |u https://doaj.org/article/b6eb1cb4061e473d8f19ee3fa9f7a49b  |z Connect to this object online.