Association of <it>SELE</it> genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level

• Main Authors: Wu Semon (Author), Hsu Lung-An (Author), Teng Ming-Sheng (Author), Lin Jeng-Feng (Author), Chang Hsien-Hsun (Author), Sun Yu-Chen (Author), Chen Hsuan-Pu (Author), Ko Yu-Lin (Author)
• Format: Book
• Published: BMC, 2012-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of <it>SELE</it>-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.</p> <p>Methods</p> <p>Five hundred twenty individuals were enrolled. Seven tagging <it>SELE</it> single nucleotide polymorphisms were analyzed.</p> <p>Results</p> <p><it>SELE</it> genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (<it>P</it> < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (<it>P</it> = 0.0490). One <it>SELE</it> SNP, (rs3917406, <it>P</it> = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of <it>SELE</it> SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (<it>P</it> = 0.002, interaction <it>P</it> = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).</p> <p>Conclusion</p> <p><it>SELE</it> genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of <it>SELE</it> genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.</p>

Item Description

10.1186/1471-2350-13-115
1471-2350