DNA methylation profiles of ovarian cysts resemble ovarian tissues but not endometrial tissues

Abstract Introduction Endometriosis is a heritable, complex chronic inflammatory disease, for which much of the causal pathogenic mechanism remain unknown.Despite the high prevalence of ovarian chocolate cyst, its origin is still under debate. Methods Prevailing retrograde menstruation model predict...

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Main Authors: Xiaohui Zhang (Author), Xiaojing Zhao (Author), Jiapo Wang (Author), Yifang Zhang (Author), Jinhong Chen (Author)
Format: Book
Published: BMC, 2024-06-01T00:00:00Z.
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001 doaj_b7012177f16b457b97c9903e695838d5
042 |a dc 
100 1 0 |a Xiaohui Zhang  |e author 
700 1 0 |a Xiaojing Zhao  |e author 
700 1 0 |a Jiapo Wang  |e author 
700 1 0 |a Yifang Zhang  |e author 
700 1 0 |a Jinhong Chen  |e author 
245 0 0 |a DNA methylation profiles of ovarian cysts resemble ovarian tissues but not endometrial tissues 
260 |b BMC,   |c 2024-06-01T00:00:00Z. 
500 |a 10.1186/s13048-024-01440-1 
500 |a 1757-2215 
520 |a Abstract Introduction Endometriosis is a heritable, complex chronic inflammatory disease, for which much of the causal pathogenic mechanism remain unknown.Despite the high prevalence of ovarian chocolate cyst, its origin is still under debate. Methods Prevailing retrograde menstruation model predicts that ectopic endometrial cells migrate and develop into ovarian chocolate cyst. However, other models were also proposed. Genome-wide association studies (GWASs) have proved successful in identifying common genetic variants of moderate effects for various complex diseases. Results A growing body of evidence shows that the remodeling of retrograde endometrial tissues to the ectopic endometriotic lesions involves multiple epigenetic alterations, such as DNA methylation, histone modification, and microRNA expression.Because DNA methylation states exhibit a tissue specific pattern, we profiled the DNA methylation for ovarian cysts and paired eutopic endometrial and ovarian tissues from four patients. Surprisingly, DNA methylation profiles showed the ovarian cysts were closely grouped with normal ovarian but not endometrial tissues. Conclusions These results suggested alterative origin of ovarian cysts or strong epigenetic reprogramming of infiltrating endometrial cells after seeding the ovarian tissue. The data provide contributing to the pathogenesis and pathophysiology of endometriosis. 
546 |a EN 
690 |a Ovarian endometriosis 
690 |a DNA methylation 
690 |a Tissue of origin 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
655 7 |a article  |2 local 
786 0 |n Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-13 (2024) 
787 0 |n https://doi.org/10.1186/s13048-024-01440-1 
787 0 |n https://doaj.org/toc/1757-2215 
856 4 1 |u https://doaj.org/article/b7012177f16b457b97c9903e695838d5  |z Connect to this object online.