Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models

• المؤلفون الرئيسيون: Ilaria Dettori (مؤلف), Irene Fusco (مؤلف), Irene Bulli (مؤلف), Lisa Gaviano (مؤلف), Elisabetta Coppi (مؤلف), Federica Cherchi (مؤلف), Martina Venturini (مؤلف), Lorenzo Di Cesare Mannelli (مؤلف), Carla Ghelardini (مؤلف), Alessio Nocentini (مؤلف), Claudiu T. Supuran (مؤلف), Anna Maria Pugliese (مؤلف), Felicita Pedata (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to pH regulation. A new generation of CA inhibitors, AN11-740 and AN...