Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models

• Main Authors: Ilaria Dettori (Author), Irene Fusco (Author), Irene Bulli (Author), Lisa Gaviano (Author), Elisabetta Coppi (Author), Federica Cherchi (Author), Martina Venturini (Author), Lorenzo Di Cesare Mannelli (Author), Carla Ghelardini (Author), Alessio Nocentini (Author), Claudiu T. Supuran (Author), Anna Maria Pugliese (Author), Felicita Pedata (Author)
• Format: Bog
• Udgivet: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Fag: article
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Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to pH regulation. A new generation of CA inhibitors, AN11-740 and AN...