Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models

• Главные авторы: Ilaria Dettori (Автор), Irene Fusco (Автор), Irene Bulli (Автор), Lisa Gaviano (Автор), Elisabetta Coppi (Автор), Federica Cherchi (Автор), Martina Venturini (Автор), Lorenzo Di Cesare Mannelli (Автор), Carla Ghelardini (Автор), Alessio Nocentini (Автор), Claudiu T. Supuran (Автор), Anna Maria Pugliese (Автор), Felicita Pedata (Автор)
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• Опубликовано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предметы: article
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Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to pH regulation. A new generation of CA inhibitors, AN11-740 and AN...