A head-to-head comparison of conjugation methods for VHHs: Random maleimide-thiol coupling versus controlled click chemistry
Targeted delivery of therapeutics is an attractive strategy for vascular diseases. Recently, variable domains of heavy-chain-only antibodies (VHHs) have gained momentum as targeting ligands to achieve this. Targeting ligands need adequate conjugation to the preferred delivery platform. When choosing...
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Main Authors: | Marc V.A. van Moorsel (Author), Rolf T. Urbanus (Author), S. Verhoef (Author), C.A. Koekman (Author), Maurice Vink (Author), T. Vermonden (Author), Coen Maas (Author), Gerard Pasterkamp (Author), Raymond M. Schiffelers (Author) |
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Format: | Book |
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Elsevier,
2019-12-01T00:00:00Z.
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Online Access: | Connect to this object online. |
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