Noradrenaline Induces Clock Gene Per1 mRNA Expression in C6 Glioma Cells Through β2-Adrenergic Receptor Coupled With Protein Kinase A - cAMP Response Element Binding Protein (PKA-CREB) and Src-Tyrosine Kinase - Glycogen Synthase Kinase-3β (Src-GSK-3β)

• Main Authors: Norimitsu Morioka (Author), Tatsuhiko Sugimoto (Author), Masato Tokuhara (Author), Toshihiro Dohi (Author), Yoshihiro Nakata (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Astrocytes in the hypothalamic suprachiasmatic nucleus, site of the master circadian pacemaker, play an essential role in the regulation of systemic circadian rhythms. To evaluate involvement of noradrenergic systems in regulation of circadian variation of clock-genes in astrocytes, we investigated...