Cover Image

Antiparasitic Behavior of Trifluoromethylated Pyrazole 2-Amino-1,3,4-thiadiazole Hybrids and Their Analogues: Synthesis and Structure-Activity Relationship

A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of Leishmania amazonensis and the epimastigote form o...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jeniffer do Nascimento Ascencio Camargo (Author), Karlos Eduardo Pianoski (Author), Mariellen Guilherme dos Santos (Author), Danielle Lazarin-Bidóia (Author), Hélito Volpato (Author), Sidnei Moura (Author), Celso Vataru Nakamura (Author), Fernanda Andreia Rosa (Author)
Format:	Book
Published:	Frontiers Media S.A., 2020-10-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents
by: Serban G, et al.
Published: (2018)

Synthesis of Some New Substituted 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives
by: Amena A. Ahmed
Published: (2018)

Synthesis and properties of some 3-(5-(4-methoxyphenyl)pyrazol-3-yl)-6-R-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles
by: S. O. Fedotov, et al.
Published: (2022)

Synthesis and Preliminary Antimicrobial Study of 2-Amino-5-Mercapto-1,3,4-Thiadiazole Derivatives
by: Husam A. Ameen, et al.
Published: (2017)

Synthesis and Preliminary Antimicrobial Study of 2-Amino-5-Mercapto-1,3,4-Thiadiazole Derivatives
by: Husam A. Ameen, et al.
Published: (2017)

Synthesis of 2- alkyl/phenyl -5-Substituted 1,3,4- Thiadiazoles
by: Khalid Daoud, et al.
Published: (2014)

Assessment of pharmacological activity and bioavailability of the new derivative 1,3,4-thiadiazole
by: Nikita S. Popov, et al.
Published: (2018)

Synthesis and Antibacterial Activity of bis Heterocyclic Derivatives of 1,3,4-thiadiazole
by: Ahlam A. Al-jubouri, et al.
Published: (2017)

Synthesis and Antibacterial Activity of bis Heterocyclic Derivatives of 1,3,4-thiadiazole
by: Ahlam A. Al-jubouri, et al.
Published: (2017)

Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives
by: Dilipkumar Pal, et al.
Published: (2014)

Synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles from 2-(2,3-dimethylphenyl amino) benzoic acid
by: Khalid Daoud, et al.
Published: (2009)

Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-Triazole
by: Tamara alsafar, et al.
Published: (2020)

Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles
by: Shereen R. Mohamed
Published: (2009)

In silico Study of New Five-Membered Heterocyclic Derivatives Bearing (1,3,4-oxadiazole and 1,3,4-thiadiazole) As Promising Cyclooxygenase Inhibitors
by: Safa Adnan Mahmood, et al.
Published: (2024)

Synthesis and Biological evalution of some substituted 2-dibenzyl amino 1,3,4-oxadiazoles , thiadiazoles and 1,2,4-triazoles
by: Khalid Daoud, et al.
Published: (2013)

Design, synthesis, and anticancer evaluation of novel N-[5-(1,3,4,5-tetrahydroxycyclohexyl)-1,3,4-thiadiazole-2-yl] benzamide analogues through integrated computational and experimental approaches
by: Sujaritha Jayaraj, et al.
Published: (2024)

Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4-Thiadiazole Analogues for Potential Scaffold
by: Sagar Sahu, et al.
Published: (2021)

Synthesis Of 2-Benzamidomethyl-5-Substituted Amino-1,3,4-Thiadiazoles-2,5-Disubstituted 1,3,4-Oxadiazole and 4,5-Disubstituted 1,2,4-Triazole-3-Thiol
by: K. M. Daoud, et al.
Published: (2012)

Mechanism-based approaches of 1,3,4 thiadiazole scaffolds as potent enzyme inhibitors for cytotoxicity and antiviral activity
by: Davinder Kumar, et al.
Published: (2023)

Synthesis, Docking and Acetylcholinesterase Inhibitory Evaluation of 1,3,4-Thiadiazole Derivatives as Potential Anti-Alzheimer Agents
by: Ahmad Mohammadi-Farani, et al.
Published: (2024)

Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides
by: E. Q. Mahmood, et al.
Published: (2013)

Synthesis of New Î²-adrenoceptor Blocking Agent Including 1,3,4 Thiadiazole with Expected Adrenoceptor Blocking Activity
by: Salah H. Zain Al-Abdeen, et al.
Published: (2017)

Synthesis of New B-adrenoceptor Blocking Agent Including 1,3,4 Thiadiazole with Expected Adrenoceptor Blocking Activity
by: Salah H. Zain Al-Abdeen, et al.
Published: (2017)

Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent
by: Min Z, et al.
Published: (2020)

Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages
by: Serena Tedesco, et al.
Published: (2018)

Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis
by: Qi Wang, et al.
Published: (2022)

Synthesis and Study of Some 4-Chlorophenoxy Methyl Substituted amido1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and 1,2,4-Triazoles from 4-Chloro phenoxy acetic acid
by: Mudhar A. Othman, et al.
Published: (2013)

5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents
by: Gomha SM, et al.
Published: (2018)

Doxorubicin-Loaded Iron Oxide Nanoparticles Induce Oxidative Stress and Cell Cycle Arrest in Breast Cancer Cells
by: Elisa Parcero Hernandes, et al.
Published: (2023)

Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues
by: Alam MJ, et al.
Published: (2016)

Synthesis and properties of 5-(((5-amino-1,3,4-thiadiazole-2-yl)thio)methyl)-4-phenyl-1,2,4-triazole-3-thione and its some S-derivatives
by: A. S. Hotsulia, et al.
Published: (2020)

New 5-Aryl-1,3,4-Thiadiazole-Based Anticancer Agents: Design, Synthesis, In Vitro Biological Evaluation and In Vivo Radioactive Tracing Studies
by: Rana M. El-Masry, et al.
Published: (2022)

Synthesis and properties of 7-((6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)methyl)theophyllines
by: K. D. Bakumovska, et al.
Published: (2023)

Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles
by: O. A. Bihdan, et al.
Published: (2017)

1,3,4-Thiadiazole and 1,2,4-triazole-3(4 H )-thione bearing salicylate moiety: synthesis and evaluation as anti- Candida albicans
by: Awwad Abdoh Radwan, et al.
Published: (2017)

Antifungal and Antiparasitic Drug Delivery
Published: (2020)

Nanoparticles for antiparasitic drug delivery
by: Yuzhu Sun, et al.
Published: (2019)

Antifungal and Antiparasitic Drug Delivery
by: Juan José Torrado, et al.
Published: (2020)

Antimicrobial Resistance Challenged with Platinum(II) and Palladium(II) Complexes Containing 1,10-Phenanthroline and 5-Amino-1,3,4-Thiadiazole-2(3H)-Thione in <i>Campylobacter jejuni</i>
by: Meiry Leandra de Lacerda, et al.
Published: (2022)

Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of 1,3,4-Thiadiazole Derivatives of 3-Aminopyridin-2(1<i>H</i>)-ones
by: Zarina Shulgau, et al.
Published: (2024)