Modulating the expression of tumor suppressor genes using activating oligonucleotide technologies as a therapeutic approach in cancer
Tumor suppressor genes (TSGs) are frequently downregulated in cancer, leading to dysregulation of the pathways that they control. The continuum model of tumor suppression suggests that even subtle changes in TSG expression, for example, driven by epigenetic modifications or copy number alterations,...
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Elsevier,
2023-03-01T00:00:00Z.
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