Aluminum toxicity induced Alzheimer's Disease and its potential treatment using antioxidants - a review
Abstract Over the years, a handful of drugs have been approved to be used in the fight against Alzheimer's Disease but unfortunately none of these drugs have proven to be solid-treatments. Alzheimer's Disease is one of the most prominent diseases observed in the elderly population. In this...
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Universidade de São Paulo,
2023-11-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_b7d0de73f46c47af8e41c8ae8aa4bec6 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Rishi Choudhury |e author |
| 700 | 1 | 0 | |a Harsha Ashtekar |e author |
| 700 | 1 | 0 | |a Kartik B. Khot |e author |
| 700 | 1 | 0 | |a Magrita Malngiang |e author |
| 700 | 1 | 0 | |a Merugumolu Vijay Kumar |e author |
| 700 | 1 | 0 | |a Soumi Mandal |e author |
| 700 | 1 | 0 | |a Barnali Das |e author |
| 245 | 0 | 0 | |a Aluminum toxicity induced Alzheimer's Disease and its potential treatment using antioxidants - a review |
| 260 | |b Universidade de São Paulo, |c 2023-11-01T00:00:00Z. | ||
| 500 | |a 2175-9790 | ||
| 500 | |a 10.1590/s2175-97902023e21587 | ||
| 520 | |a Abstract Over the years, a handful of drugs have been approved to be used in the fight against Alzheimer's Disease but unfortunately none of these drugs have proven to be solid-treatments. Alzheimer's Disease is one of the most prominent diseases observed in the elderly population. In this review article, we discuss how aluminum toxicity can lead to neuro degeneration. Aluminum is abundantly present on the earth's crust and hence becomes easily accessible to man. This makes it an obvious choice in the preparation of numerous substances, packaging, etc. Such wide usage of the metal can pave an easy access to the body, leading to toxicities. Aluminum toxicity has been linked to oxidative stress which has an established relation with neurodegeneration and mitochondrial damage. We also discuss how consumption of antioxidants can be useful in combating oxidative stress. | ||
| 546 | |a EN | ||
| 690 | |a Alzheimer's Disease | ||
| 690 | |a Aluminum | ||
| 690 | |a Toxicity | ||
| 690 | |a Oxidative stress | ||
| 690 | |a Neurodegeneration | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Brazilian Journal of Pharmaceutical Sciences, Vol 59 (2023) | |
| 787 | 0 | |n http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100800&tlng=en | |
| 787 | 0 | |n https://doaj.org/toc/2175-9790 | |
| 856 | 4 | 1 | |u https://doaj.org/article/b7d0de73f46c47af8e41c8ae8aa4bec6 |z Connect to this object online. |