Phytochemical Screening and Anti-nociceptive Properties of the Ethanolic Leaf Extract of Trema Cannabina Lour
Purpose: The present study was designed to investigate the anti-nociceptive activity of ethanolic leaf extract of Trema cannabina Lour (family: Cannabaceae) in experimental animal models. Methods: The anti-nociceptive action was carried out against two types of noxious stimuli, thermal (hot plate an...
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Tabriz University of Medical Sciences,
2013-02-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_b7d690e23e22433faace35e38623b90a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hira Arpona |e author |
| 700 | 1 | 0 | |a Dey Shubhra Kanti |e author |
| 700 | 1 | 0 | |a Howlader Sariful Islam |e author |
| 700 | 1 | 0 | |a Ismet Ara Jahan |e author |
| 700 | 1 | 0 | |a Hossain Hemayet |e author |
| 700 | 1 | 0 | |a Ahmed Arif |e author |
| 245 | 0 | 0 | |a Phytochemical Screening and Anti-nociceptive Properties of the Ethanolic Leaf Extract of Trema Cannabina Lour |
| 260 | |b Tabriz University of Medical Sciences, |c 2013-02-01T00:00:00Z. | ||
| 500 | |a 10.5681/apb.2013.017 | ||
| 500 | |a 2228-5881 | ||
| 500 | |a 2251-7308 | ||
| 520 | |a Purpose: The present study was designed to investigate the anti-nociceptive activity of ethanolic leaf extract of Trema cannabina Lour (family: Cannabaceae) in experimental animal models. Methods: The anti-nociceptive action was carried out against two types of noxious stimuli, thermal (hot plate and tail immersion tests) and chemical (acetic acid-induced writhing) in mice. Results: Phytochemical analysis of crude extract indicated the presence of reducing sugar, tannins, steroid and alkaloid types of secondary metabolites. Crude extract of T. cannabina (500 mg/kg dose) showed maximum time needed for the response against thermal stimuli (6.79±0.15 seconds) which is comparable to diclofenac sodium (8.26±0.14 seconds) in the hot plate test. Hot tail immersion test also showed similar results as in hot plate test. At the dose of 250 and 500 mg/kg body weight, the extract showed significantly and in a dose-dependent (p<0.001) reduction in acetic acid induced writhing in mice with a maximum effect of 47.56% reduction at 500 mg/kg dose comparable to that of diclofenac sodium (67.07%) at 25 mg/kg. Conclusion: The obtained results tend to suggest the Anti-nociceptive activity of ethanolic leaf extract of Trema cannabina and thus provide the scientific basis for the traditional uses of this plant part as a remedy for pain. | ||
| 546 | |a EN | ||
| 690 | |a Trema cannabina | ||
| 690 | |a Anti-nociceptive | ||
| 690 | |a Hot plate test | ||
| 690 | |a Tail immersion test | ||
| 690 | |a Acetic acid induced writhing test | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Advanced Pharmaceutical Bulletin, Vol 3, Iss 1, Pp 103-108 (2013) | |
| 787 | 0 | |n http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-103.pdf | |
| 787 | 0 | |n https://doaj.org/toc/2228-5881 | |
| 787 | 0 | |n https://doaj.org/toc/2251-7308 | |
| 856 | 4 | 1 | |u https://doaj.org/article/b7d690e23e22433faace35e38623b90a |z Connect to this object online. |