Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion

• Main Authors: Andrea Marino (Author), Edoardo Campanella (Author), Stefano Stracquadanio (Author), Maddalena Calvo (Author), Giuseppe Migliorisi (Author), Alice Nicolosi (Author), Federica Cosentino (Author), Stefano Marletta (Author), Serena Spampinato (Author), Pamela Prestifilippo (Author), Stefania Stefani (Author), Bruno Cacopardo (Author), Giuseppe Nunnari (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

This comprehensive review examines the unique attributes, distinctions, and clinical implications of ceftazidime-avibactam (CAZ-AVI) and meropenem-vaborbactam (MEM-VAB) against difficult-to-treat <i>Enterobacterales</i> infections. Our manuscript explores these antibiotics' pharmacokinetic and pharmacodynamic properties, antimicrobial activities, in vitro susceptibility testing, and clinical data. Moreover, it includes a meticulous examination of comparative clinical and microbiological studies, assessed and presented to provide clarity in making informed treatment choices for clinicians. Finally, we propose an expert opinion from a microbiological and a clinical point of view about their use in appropriate clinical settings. This is the first review aiming to provide healthcare professionals with valuable insights for making informed treatment decisions when combating carbapenem-resistant pathogens.

Item Description

10.3390/antibiotics12101521
2079-6382