Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration

• मुख्य लेखकों: Yusuke Hatakawa (लेखक), Akiko Tanaka (लेखक), Tomoyuki Furubayashi (लेखक), Rina Nakamura (लेखक), Motomi Konishi (लेखक), Toshifumi Akizawa (लेखक), Toshiyasu Sakane (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

We have recently reported Catalytides (Catalytic peptides) JAL-TA9 (YKGSGFRMI) and ANA-TA9 (SKGQAYRMI), which are the first Catalytides found to cleave Aβ42. Although the Catalytides must be delivered to the brain parenchyma to treat Alzheimer's disease, the blood-brain barrier (BBB) limits the...