Simultaneous Imaging and Therapy Using Epitope-Specific Anti-Epidermal Growth Factor Receptor (EGFR) Antibody Conjugates

• Main Authors: Anjong Florence Tikum (Author), Anand Krishnan Nambisan (Author), Jessica Pougoue Ketchemen (Author), Hanan Babeker (Author), Musharraf N. Khan (Author), Emina E. Torlakovic (Author), Humphrey Fonge (Author)
• 格式: 图书
• 出版: MDPI AG, 2022-09-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Matuzumab and nimotuzumab are anti-EGFR monoclonal antibodies that bind to different epitopes of domain III of EGFR. We developed ⁸⁹Zr-matuzumab as a PET probe for diagnosis/monitoring of response to treatment of a noncompeting anti-EGFR nimotuzumab antibody drug conjugate (AD...