Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential <i>Mycobacterium tuberculosis</i> Phosphopantetheinyl Transferase PptT

• Κύριοι συγγραφείς: Alistair S. Brown (Συγγραφέας), Jeremy G. Owen (Συγγραφέας), James Jung (Συγγραφέας), Edward N. Baker (Συγγραφέας), David F. Ackerley (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2021-07-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

A recently-validated and underexplored drug target in <i>Mycobacterium tuberculosis</i> is PptT, an essential phosphopantetheinyl transferase (PPTase) that plays a critical role in activating enzymes for both primary and secondary metabolism. PptT possesses a deep binding pocket that doe...